3D tissue imaging use cases across spatial biology

See how 3D tissue imaging of full-thickness skin biopsies reveals immune–epithelial interactions, nerve fibers, and microvascular changes in atopic dermatitis. This use case highlights how 3D histology and spatial profiling can quantify inflammation patterns and treatment response across the entire lesion.

This case study focuses on immune excluded tumors, using 3D tissue imaging and AI powered analysis to map lymphocyte patterns and exclusion zones across the whole tumor microenvironment. It illustrates how 3D spatial biology clarifies why some immunotherapies fail despite high target expression.

A side-by-side comparison of classic 2D histology versus 3D tissue imaging on the same specimen. This use case shows where 2D undercounts structures, misses rare events, or misrepresents tissue architecture, and how whole tissue 3D datasets provide a truer ground truth for digital pathology and AI models.

3D imaging of tertiary lymphoid structures in non-small cell lung cancer, with spatial segmentation and quantification of TLS size. This use case demonstrates how 3D histology supports TLS-based biomarkers and patient stratification in immuno-oncology.

A broader overview of how whole tissue 3D imaging, Aurora 3D workflows, and ground truth 3D data support immuno oncology programs.