Dermatology applications

3D dermatology imaging for full-volume skin analysis

The 3D Derm Score™ Assay helps quantify skin architecture, peripheral innervation, immune infiltration, and neuroimmune interactions across intact dermatology samples.

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3D Derm Score™ Assay

A 3D digital pathology assay for the skin microenvironment

The 3D Derm Score™ Assay combines high-resolution 3D tissue imaging with quantitative tissue analysis to measure structure, cellular composition, and spatial profiling across intact dermatology samples.

Nerve fiber density

Bio-distribution

Treatment effects

Cell clusters

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3D Derm Score summary showing nerve fiber density, bio-distribution, treatment effects, and cell clusters

3D Derm Score™ readouts connect intact tissue imaging with measurable dermatology endpoints.

Why 3D dermatology imaging matters

Skin biology is spatial. Thin sections can miss the pattern.

Dermatology samples contain layered structures, long nerve fibers, immune cell clusters, follicles, and local tissue remodeling. 3D tissue imaging captures these relationships across the biopsy volume.

Traditional workflows

Limited views of a complex tissue

Single 2D sections can provide useful histology, but they may sample a small part of a biopsy and separate features that are connected in 3D.

• Small fraction of the biopsy volume
• Subtle nerve and immune patterns can be missed
• Neuroimmune interactions are harder to interpret in context
3D tissue imaging

Full-volume insight for quantitative dermatology

Whole tissue imaging preserves spatial context, enabling quantitative tissue analysis of structures and cell relationships across intact dermatology samples.

✓ Long nerve fibers and branching patterns
✓ Immune clustering and nerve proximity
✓ Hair follicles, pilosebaceous units, and tissue architecture

From qualitative impressions to reproducible metrics. The 3D Derm Score™ Assay combines whole tissue imaging with quantitative analysis to support dermatology drug development, biomarker discovery, and translational research.

Spatial profiling in 3D

Summit AI™ for dermatology

From full-sample skin imaging to structured disease readouts

Summit AI™ extends the 3D Derm Score™ workflow by connecting full-sample 3D tissue imaging with AI-powered analysis, spatial profiling, and quantitative tissue signatures across dermatology datasets.

Skin architecture Immune organization Nerve interactions Disease remodeling
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Summit AI platform visual for AI-powered 3D tissue imaging and dermatology analysis

3D Derm Score™ workflow

Dermatology assays built on the Aurora 3D™ workflow

Start with intact skin tissue, capture high-resolution 3D tissue imaging, process large volumetric datasets, and apply AI-powered analysis for quantitative dermatology readouts.

Input

Intact skin tissue

Skin and scalp samples prepared for whole tissue 3D imaging.

Fluorescent intact 3D skin samples for dermatology imaging

3D imaging

3Di HOTLS

High-resolution 3D tissue imaging across intact dermatology samples.

3Di HOTLS microscope for high-resolution 3D tissue imaging

Data management

3Dm

Processing, correction, organization, and preparation of large 3D datasets.

3Dm data management interface for large 3D tissue datasets

AI analysis

3Dai

AI-powered analysis for cells, structures, spatial relationships, and quantitative tissue analysis.

3Dai analysis interface for AI-powered analysis of 3D tissue datasets

Output

Skin insights

Quantitative readouts for skin architecture, nerves, immune cells, follicles, and remodeling.

Dermatology insights report with 3D skin analysis and quantitative readouts
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Marker panels

Flexible panels for skin and neuroimmune profiling

Different dermatology studies require different readouts. The 3D Derm Score™ Assay supports standard panels and customized marker strategies for 3D tissue imaging, spatial profiling, and quantitative tissue analysis.

Option A

Select a pre-optimized panel

Use a dermatology-focused marker panel for nuclei, nerves, and immune cells to support skin microenvironment analysis.

Example markers shown
3D Derm Score marker panel with TO-PRO-3, PGP9.5, and CD45
Option B

Design your panel

Adapt the marker strategy to your experimental goals, tissue type, species, and dermatology endpoint.

Custom marker strategy
General customizable marker panel with Marker 1, Marker 2, and Marker 3
Optimized markers Staining examples

Example datasets

See 3D dermatology imaging applied to real tissue datasets

Explore examples of intact skin and scalp imaging, including peripheral innervation, immune infiltration, tissue architecture, and neuroimmune spatial profiling.

Who it supports

Built for teams studying skin disease in spatial context

The 3D Derm Score™ Assay supports dermatology programs that need 3D tissue imaging, spatial profiling, and quantitative tissue analysis across intact skin samples.

Translational research teams

Study immune infiltration, peripheral innervation, neuroimmune interactions, and tissue remodeling in full biopsy context.

Mechanism of action Biomarker discovery

Dermatology drug programs

Compare treatment effects across intact dermatology samples using volumetric datasets and quantitative analysis.

Atopic dermatitis Alopecia Inflammation

Academic dermatology labs

Explore skin architecture, nerve distribution, immune organization, follicles, and disease remodeling in 3D.

Whole tissue imaging 3D digital pathology

Use the assay as a service or as part of an in-house Aurora 3D™ workflow. Alpenglow supports dermatology studies from intact tissue preparation through 3D imaging, data processing, and AI-powered analysis.

Start a dermatology study

Ready to see skin biology in full 3D context?

Use Alpenglow’s 3D tissue imaging, digital pathology workflows, and AI-powered analysis to study skin architecture, peripheral innervation, immune infiltration, and neuroimmune interactions across intact dermatology samples.

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Assay service

Send dermatology samples for 3D imaging, processing, and quantitative tissue analysis.

In-house platform

Bring the Aurora 3D™ workflow into your lab with 3Di, 3Dm, and 3Dai.

Dermatology readouts

Generate spatial profiling readouts for nerves, immune cells, follicles, architecture, and remodeling.