3D spatial biology platform

Turn intact tissue into quantitative 3D data

Intact 3D tissue imaging, spatial profiling, and AI powered analysis in a single, end-to-end imaging platform.

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Trusted by leading research teams and eight of the top 10 pharmaceutical companies. 3D tissue imaging AI analysis Spatial profiling Digital pathology

From tissue to 3D insight

Send tissue for 3D imaging

Access clearing, staining, imaging, visualization, and quantitative analysis through Alpenglow’s 3D histology services.

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Evaluate 3Di^™ HOTLS

Scout large tissue volumes, then zoom into selected regions of interest at high resolution.

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Analyze with
Summit AI™

Turn multimodal 3D tissue datasets into quantitative, reviewable biological readouts.

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Aurora 3D™: 3D Spatial Biology Platform for whole tissue imaging

End-to-end 3D imaging, data management, and AI analysis in one platform.

3Di^™ HOTLS

The 3Di™ is a dual-path open-top light-sheet microscope for whole-sample imaging and high-resolution imaging, operated via the LUMI interface.

3Dm^™

3Dm™ aligns, organizes, and serves large volumetric datasets, ready for analysis and review.

3Dai^™

3Dai™ quantifies cells, structures, and spatial patterns for cell-level spatial measurements.

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Why 3D?

See what thin sections can miss

Conventional slides capture selected tissue planes. Intact 3D imaging preserves spatial context across the full tissue volume, helping reveal structures, cell neighborhoods, vessels, nerves, and patterns that may be missed in 2D.

Why 3D tissue imaging matters See 3D tissue examples

Solutions by role

Find the right 3D tissue workflow for your research goal.

Dermatology Investigator

Map skin architecture, nerves, vessels, and inflammation in 3D.

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Immunology Researcher

Visualize immune organization and spatial relationships across intact tissue.

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Translational Scientist

Connect tissue architecture with quantitative spatial readouts.

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Imaging Facility Director

Support advanced 3D imaging workflows across research programs.

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Research Group Leader

Generate richer tissue data from intact samples.

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Pathologist

Review margins, structures, and spatial patterns beyond 2D slides.

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3D Tissue Imaging applications across tissues

Dermatology

Map immune cells, nerves, follicles, and tissue architecture across intact skin.

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Immuno Oncology

Visualize tumor architecture, immune organization, and spatial patterns in 3D.

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3D tissue imaging example across multiple fields

Multi Field Capabilities

Apply 3D tissue imaging across organs, model systems, and translational workflows.

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Summit AI^™

Turns 3D tissue context into quantitative data

Built for multimodal 3D tissue datasets, Summit AI™ supports visualization, QC, uncertainty metrics, spatial profiling, and AI powered analysis in one reviewable environment.

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About Alpenglow Biosciences

Redefining what’s possible in 3D spatial biology

Alpenglow Biosciences accelerates drug development and improves clinical diagnostics through AI-enabled 3D tissue imaging and digital pathology. The Aurora 3D spatial biology platform digitizes intact tissue samples, delivering quantitative 3D datasets while preserving tissue for molecular analysis.