3D spatial biology platform
Turn intact tissue into quantitative 3D data
Aurora 3D™ combines open-top light-sheet microscopy, automated volumetric data processing, and AI analysis to measure cells, structures, and spatial relationships across intact tissue.
How to work with Alpenglow
Choose how to access the 3D imaging workflow
Outsourced 3D histology
Complete workflow performed by Alpenglow
Send tissue for end-to-end 3D analysis
Ship your fixed tissue samples directly to our laboratories. Our team executes the complete pipeline: tissue clearing, staining, high-throughput 3D light-sheet imaging, and quantitative AI data extraction.
Your team defines the biological question and sends the samples. Our team performs the preparation, imaging, processing, and analysis workflow.
In-house 3D imaging platform
Instrument operated within your facility
Install the imaging workflow in your facility
Bring hybrid open-top light-sheet microscopy directly into your laboratory. Scale internal discovery with an open, multi-immersion architecture built for diverse sample formats and terabyte-scale data management.
Alpenglow supplies the microscope and connected software options. Your team operates the workflow within your laboratory or shared facility.
Applications
Where full-volume imaging changes the biological readout
Dermatology
Map skin biology across whole biopsies
Follow long nerve fibers, immune clusters, follicles, vessels, and epidermal architecture through intact skin biopsies instead of interpreting isolated tissue planes.
Nerve density, immune distribution, follicular organization, spatial distances, and regional variation.
Immuno-oncology
Quantify immune organization across intact tumors
Resolve immune infiltration, exclusion zones, tumor boundaries, collagen, vasculature, and tertiary lymphoid structures across tissue depth.
Cell density, infiltration depth, clustering, TLS volume, spatial relationships, and tissue heterogeneity.
Multi-field capabilities
Analyze connected structures across tissues
Trace villi, crypts, vessels, nerves, airways, ducts, lesions, and other connected structures across organs and model systems.
Branching, diameter, volume, morphology, density, structural continuity, and regional distribution.
Aurora 3D™ Spatial Biology Solution
Capture intact tissue. Turn the volume into quantitative data.
Imaging hardware
Acquisition
3Di™
Hybrid Open-Top Light-Sheet microscope
Image intact tissue
Capture whole-sample context and selected high-resolution regions of interest with a dual-path Scout-to-Zoom imaging workflow.
ExploreData and analysis software
Processing and quantification
3Dm™
Volumetric data management
Process the volume
Stitch, align, correct, register, and organize multichannel 3D datasets for review and downstream analysis.
Explore
3Dai™
AI-powered image analysis
Quantify the biology
Segment cells and structures, measure spatial relationships, and generate quantitative outputs across intact tissue volumes.
ExplorePeer-reviewed evidence
Research advancing 3D pathology and tissue analysis
Multimodal tissue intelligence
Summit AI
Turn full-sample tissue data into earlier, higher-confidence development decisions
Summit AI™ analyzes full-sample 3D imaging and connects multimodal data to generate quantitative tissue signatures and spatial profiles. These insights help teams identify treatment effects earlier, reduce development risk, and make stronger clinical and competitive decisions.
About Alpenglow
Building the tools and partnerships advancing 3D spatial biology
Alpenglow Biosciences develops integrated 3D tissue imaging and AI-powered analysis solutions for research, drug development, and diagnostic innovation.
Latest from Alpenglow
Where to meet us and company updates
Upcoming scientific events, partnerships, platform developments, and announcements from Alpenglow Biosciences.
Your next step
Bring your tissue question into 3D
Share your sample type, markers, and study goals. Alpenglow can help determine whether imaging services, an in-house Aurora 3D™ workflow, or quantitative analysis is the right path for your team.
Intact tissue imaging
