Discover the latest insights
Lymphocytes Cluster Near Nerves in Atopic Dermatitis
Delve into the intricate details of a lesional atopic dermatitis sample captured with cutting-edge 40X high-resolution 3D imaging. The sample is vividly stained with TO-PRO-3 blue for nuclei, PGP 9.5 white for nerves, and CD45 yellow for lymphocytes. Marvel at the precise preservation of epidermal and dermal structures and the clear visualization of immune-cell clusters in close proximity to specific nerve fibers.
3D view of Human Normal Adjacent Colorectal Cancer
Explore this cutting-edge 3D imaging of Human Normal Adjacent Colorectal Cancer
Exploring Human Placenta in 3D: A New Era in Spatial Biology
Experience the intricate architecture of human placenta tissue in this captivating 3D video, designed to showcase the power of advanced spatial biology.
Whole murine heart staining and imaging
This video captures 3D imaging of a whole murine heart, highlighting the complexity and detail of vascular structures. Smooth muscle actin (SMA) stains the blood vessels in green, providing a vivid view of their architecture, while mural cells are highlighted in purple.
Identification of B Cells and Follicular Dendritic Cells through CD21 Staining
Low resolution image of human tonsil measuring up to 3mm in x,y,z, stained with Biocare Bu32 anti-CD21. This antibody has been optimized for a variety of human tissue including FFPE samples.
Identification of Memory T-Cells through CD45RO Staining
High resolution image of human tonsil measuring up to 3mm in x,y,z, stained with Biolegend anti-CD45RO. This antibody has been optimized for a variety of human tissue including FFPE samples.
Deep Tissue Staining with anti-CD3 to Identify T-cells
Low resolution image of human tonsil measuring up to 3mm in x,y,z, stained with Biocare Medical BC33 anti-CD3. This antibody has been optimized for a variety of human tissue including FFPE samples.
Identifying cytotoxic T-cells in cleared, thick tissue samples through CD8 Staining
Low resolution image of human tonsil measuring up to 3mm in x,y,z, stained with Biocare Medical SP6 anti-CD8. This antibody has been optimized for a variety of human tissue including FFPE samples.
Low-resolution imaging of a human dorsal root ganglion (DRG) sample
This video presents low-resolution (scout) imaging of a human dorsal root ganglion (DRG) sample provided by AnaBios. The sample features computational H&E staining, with ToPro-3 highlighting nuclei and Eosin-capturing protein structures.
High-Resolution imaging of a Human Dorsal Root Ganglion (DRG) sample
This video presents high-resolution (zoom) imaging of a human dorsal root ganglion (DRG) sample provided by AnaBios. The sample features computational H&E staining, with ToPro-3 highlighting nuclei and Eosin-capturing protein structures. A fascinating visualization offering insights into DRG tissue composition.
Low-resolution whole-sample 3D imaging of a lesional Atopic Dermatitis punch biopsy
Low resolution image of a lesional Atopic Dermatitis sample stained with PGP9.5 (white) to highlight fine epidermal innervation, TO-PRO-3 (blue) for nuclear detail, and CD3 (green) to illuminate T-Cell infiltration of the Epidermis and Dermis. Image reproduced with permission from Incyte Corporation. The tissue measured approximately 2.5mm X 2.5mm X 2.5mm.
High-resolution (40X) 3D imaging of a Region of Interest in a lesional Atopic Dermatitis sample
40X image of a lesional Atopic Dermatitis samples stained with PGP9.5 (white) to highlight fine epidermal innervation, TO-PRO-3 (blue) for nuclear detail, and CD3 (green) to illuminate T-Cell infiltration of the Epidermis and Dermis. Image reproduced with permission from Incyte Corporation.
Collagen III staining and 3D imaging followed by image analysis and segmentation highlighting liver fibrosis
Incredible 3D spatial biology image of a liver biopsy with collagen III staining (yellow) followed by image analysis using a pixel classification scheme
Segmentation analysis of liver fibrosis and steatosis
Amazing 3D video of liver biopsy sample highlighting variability of steatosis.
Large volumetric 3D imaging of human colon
Large volumetric image of human colon. Welcome to the enteric nervous system!
Amazing 3D Image of an Ileocecal Sample
This human ileocecal sample contains more pixels than stars in the Milky Way galaxy! There are more than 840 billion pixels in the 3D scan of this sample encompassing a total volume of 2,350 cubic millimeters.
Journal club review: Multiplex 3D Atlas
A tour de force paper by Lin et al from the Sorger Lab at Harvard. This paper is chock full of 3D tumor architecture, tertiary lymphoid structures and spatial heterogeneity in human colorectal cancer samples. Read our key findings from the paper below.
Whole Human Brain Slice
Human brain slice optically cleared using CUBIC protocol. Brain tissue autofluorescence is shown in black and white with amyloid small molecule stain (pFTAA) is shown in green.