Deep Insights with 3D Spatial Biology

Advanced chemistry, a high-throughput light-sheet microscope, and cloud-based AI come together to deliver unmatched depth and precision in pathology.

The Challenge

Pharma R&D investment has quadrupled since 2000, yet drug approval rates remain stagnant. Pathology, a vital part of drug development and diagnostics, relies on outdated 2D analysis, subjective interpretation, and manual methods. How can we shift to a new paradigm that lowers costs and improves outcomes?

The Answer: AI-Enabled 3D insights

Alpenglow is pioneering a new frontier in digital 3D spatial biology, integrating proprietary 3D imaging technology with cloud computing and AI-powered analysis. This high-throughput, digital approach delivers unparalleled insights, accelerating discoveries and paving the way for breakthrough advancements in research.

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SEE WHAT YOU’VE BEEN MISSING

Alpenglow offers an end-to-end solution featuring sample preparation, patented open-top light-sheet microscopy, cloud-based processing and storage, 3D visualization, and AI analysis. These technologies provide a unique 3D view of Spatial Biology, uncovering insights that are impossible or impractical with 2D histology methods - such as convoluted shapes, complex cell distributions, sparse objects, and entire structures.

PARTNER WITH US

Collaborating with Alpenglow gives innovators access to advanced technology, overcoming the limitations of traditional 2D, slide-based analysis. Our services include sample preparation, cloud-based data processing and storage, and AI-powered 3D analysis. With our expertise and digital approach to pathology, we help streamline timelines and enhance success by delivering deeper insights and a greater understanding. 

  • Sample Preparation

    Using the latest techniques to accelerate thick tissue labeling in 3D and advanced clearing methods, samples are prepared for deep imaging without affecting downstream molecular assays. Samples are mounted in custom 3D-printed holders to ensure optimal imaging quality.

  • HOTLS Technology

    The Hybrid Open Top Light Sheet (HOTLS) imaging platform provides optical sectioning from mesoscopic to sub-micron scales while preserving specimen integrity for further analysis. Its open-top design enables high-throughput imaging, simultaneously accommodating dozens to hundreds of samples.

  • Experience Biology in 3D

    Discover biology as it was meant to be seen with cutting-edge 3D imaging, GPU-accelerated processing, and comprehensive 3D image analysis. Immerse yourself in digital pathology through advanced 3D visualization and a complete suite of analytical tools. Harness the power of machine learning and artificial intelligence to uncover deep insights and reveal what you may have been missing.

 Alpenglow has developed an end-to-end solution with proprietary sample preparation, patented open-top light-sheet microscopy, cloud-based data processing & storage, 3D visualization and AI analysis. These technologies combined provide a remarkable view of spatial biology to see what would not be possible or practical with 2D techniques such as convoluted shapes, complex cell distributions, sparse objects, or entire structures.

ABOUT ALPENGLOW

Alpenglow accelerates drug development and improves clinical diagnostics through AI-enabled 3D imaging technology. Our platform delivers new biological insights and more accurate results by digitizing entire samples while preserving tissue for molecular analysis. Partners benefit from exclusive technology and a greater understanding of their biology. Five of the top 10 pharmaceutical companies collaborate with Alpenglow to uncover new insights, streamline timelines, and improve success rates.

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