Steve Pemberton Steve Pemberton

Whole sample imaging of a Lesional Atopic Dermatitis punch biopsy highlighting innervation within the Dermis and Epidermis at low power resolution

Low resolution image of a lesional Atopic Dermatitis sample stained with PGP9.5 (white) to highlight fine epidermal innervation, TO-PRO-3 (blue) for nuclear detail, and CD3 (green) to illuminate T-Cell infiltration of the Epidermis and Dermis. Image reproduced with permission from Incyte Corporation. The tissue measured approximately 2.5mm X 2.5mm X 2.5mm.

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Steve Pemberton Steve Pemberton

Amazing 3D Image of an Ileocecal Sample

This human ileocecal sample contains more pixels than stars in the Milky Way galaxy! There are more than 840 billion pixels in the 3D scan of this sample encompassing a total volume of 2,350 cubic millimeters.

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Alpenglow Biosciences Alpenglow Biosciences

Journal club review: Multiplex 3D Atlas

A tour de force paper by Lin et al from the Sorger Lab at Harvard. This paper is chock full of 3D tumor architecture, tertiary lymphoid structures and spatial heterogeneity in human colorectal cancer samples. Read our key findings from the paper below.

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Alpenglow Biosciences Alpenglow Biosciences

Whole Human Brain Slice

Human brain slice optically cleared using CUBIC protocol. Brain tissue autofluorescence is shown in black and white with amyloid small molecule stain (pFTAA) is shown in green.

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Alpenglow Biosciences Alpenglow Biosciences

Cleared Mouse Tissue

Mouse fat pad with labeled blood vessels using lectin (red), macrophages immuno-fluorescently labelled with CD68 (turquoise), and nerves labelled with PGP9.5 (green)

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